ODCs

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1 OMIM reference -
1 associated gene
5 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 3

1 OMIM reference -
1 associated gene
14 signs/symptoms

Pyogenic bacterial infections due to MyD88 deficiency

Combined immunodeficiency due to DOCK8 deficiency


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MYD88	(0.72)	DOCK8

Citations in the biomedical literature:

Pyogenic bacterial infections due to MyD88 deficiency		Combined immunodeficiency due to DOCK8 deficiency
	Synonym(s): - MyD88 deficiency		Synonym(s): - CID due to DOCK8 deficiency - Combined immunodeficiency due to dedicator of cytokinesis 8 protein deficiency - DOCK8 immunodeficiency syndrome

	Classification (Orphanet): - Rare genetic disease - Rare immune disease		Classification (Orphanet): - Rare genetic disease - Rare immune disease

	Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: child / adolescent Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: child / adolescent Type of inheritance: autosomal recessive

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Autosomal recessive inheritance - Chronic skin infection / ulcerations / ulcers / cancrum - Nasal congestion / sinusitis / rhinitis / rhinorrhea

Pyogenic bacterial infections due to MyD88 deficiency		Combined immunodeficiency due to DOCK8 deficiency
	Very frequent - Immunodeficiency / increased susceptibility to infections / recurrent infections Occasional - Fever / chilling		Very frequent - Agammaglobulinemia / hypogammaglobulinemia / B-cell deficiency - Asthma / bronchospasm - Chronic / relapsing otitis - Eczema - Ground-glass / reticular / alveolar / interstitial lung / pulmonary opacity - Repeat respiratory infections - Severe allergic reaction / atopy - T-cell deficiency / cellular immunity deficiency - Warts / papillomas Occasional - Neoplasms / tumors - Skin / cutaneous neoplasm / tumor / carcinoma / cancer (excluding melanoma)